Ceritinib dihydrochloride
Cat. No.：YN440336
CAS No. ：1380575-43-8
规格
价格(RMB)
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| 产品名称: | Ceritinib dihydrochloride |
| CAS No.: | 1380575-43-8 |
| Chemical Name: | |
| Synonyms: | 双盐酸盐色瑞替尼; LDK378 dihydrochloride |
| 分子量: | 631.06 |
| 分子式: | C₂₈H₃₈Cl₃N₅O₃S |
| SMILES: | CC(C)OC1=CC(C2CCNCC2)=C(C)C=C1NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ceritinib dihydrochloride (LDK378 dihydrochloride) 是一种选择性，口服可生物利用且具有 ATP 竞争性的ALK酪氨酸激酶抑制剂，IC50为 200 pM。Ceritinib dihydrochloride (LDK378 dihydrochloride) 还抑制IGF-1R，InsR和STK22D，IC50值分别为 8、7 和 23 nM。Ceritinib dihydrochloride (LDK378 dihydrochloride) 显示出良好的抗肿 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
