HG-14-10-04
Cat. No.：YN440348
CAS No. ：1356962-34-9
规格
价格(RMB)
库存
| 产品名称: | HG-14-10-04 |
| CAS No.: | 1356962-34-9 |
| Chemical Name: | 5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2-pyrimidinamine |
| Synonyms: | HG-14-10-04;[5-Chloro-4-(1H-indol-3-yl)-pyrimidin-2-yl]-{2-methoxy-4-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-phenyl}-amine;5-Chloro-4-(1H-indol-3-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine;5-chloro-4-(1H-ind |
| 分子量: | 532.08 |
| 分子式: | C₂₉H₃₄ClN₇O |
| SMILES: | ClC1=CN=C(NC2=CC=C(N3CCC(N4CCN(C)CC4)CC3)C=C2OC)N=C1C5=CNC6=CC=CC=C65 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HG-14-10-04 (example 10) is a potent and specificALKinhibitor withIC50of 20 nM. |
| IC50和靶点: | [{name:"EGFRLR/TM:15.6 nM (IC50)"},{name: "EGFR19del/TM/CS:22.6 nM (IC50)"},{name: "EGFRLR/TM/CS:124.5 nM (IC50)"},{name: "ALK:20 nM (IC50)"}] |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Aquila, B., Kamhi, V., Peng, B., et al.Preparation of substituted pyrimidinamines as ALK kinase inhibitorsUS20120028924A1,1-54(2012)
