CEP-37440
Cat. No.：YN440350
CAS No. ：1391712-60-9
规格
价格(RMB)
库存
| 产品名称: | CEP-37440 |
| CAS No.: | 1391712-60-9 |
| Chemical Name: | 2-[[5-chloro-2-[[(6S)-6,7,8,9-tetrahydro-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-N-methyl-benzamide |
| Synonyms: | CEP37440 |
| 分子量: | 580.12 |
| 分子式: | C₃₀H₃₈ClN₇O₃ |
| SMILES: | O=C(NC)C1=CC=CC=C1NC2=NC(NC3=CC=C4C(CCC[C@H](N5CCN(CCO)CC5)C4)=C3OC)=NC=C2Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CEP-37440是新型FAK和ALK双重抑制剂，IC50分别为2.3 nM和120 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ott, G.R., Cheng, M., Learn, K.S., et al.Discovery of clinical candidate CEP-37440, a selective inhibitor of focal adhesion kinase (FAK) and anaplastic lymphoma kinase (ALK)J. Med. Chem.59(16),7478-7496(2016)
Salem, I., Alsalahi, M., Chervoneva, I., et al.The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cellsBreast Cancer Res.18(1),37(2016)
