X-376
Cat. No.：YN440363
CAS No. ：1365267-27-1
规格
价格(RMB)
库存
| 产品名称: | X-376 |
| CAS No.: | 1365267-27-1 |
| Chemical Name: | 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-3-pyridazinecarboxamide |
| Synonyms: | X-396,Ensartinib,恩沙替尼 |
| 分子量: | 547.41 |
| 分子式: | C₂₅H₂₅Cl₂FN₆O₃ |
| SMILES: | O=C(C1=NN=C(N)C(O[C@@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1)NC3=CC=C(C(N4CCN(C)CC4)=O)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | X-376 是一种有效的高特异性ALK酪氨酸激酶抑制剂 (TKI) (IC50=0.61 nM)。X-376 是MET的较低效抑制剂 (IC50=0.69 nM)。X-376 具有有效的抗肿瘤活性。 |
| IC50和靶点: | [{name:"ALK:0.61 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lovly, C.M., Heuckmann, J.M., de Stanchina, E., et al.Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitorsCancer Res.71(14),4920-4931(2011)
