Crizotinib
Cat. No.：YN440407
CAS No. ：877399-52-5
规格
价格(RMB)
库存
| 产品名称: | Crizotinib |
| CAS No.: | 877399-52-5 |
| Chemical Name: | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine |
| Synonyms: | 克唑替尼; PF-02341066 |
| 分子量: | 450.34 |
| 分子式: | C₂₁H₂₂Cl₂FN₅O |
| SMILES: | ClC1=C(F)C=CC(Cl)=C1[C@H](OC2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Crizotinib (PF-02341066) 是一种具有口服活性的，ATP 竞争性的ALK和c-Met抑制剂，IC50分别为 20 和 8 nM。在细胞的实验中，Crizotinib 抑制 NPM-ALK 的酪氨酸磷酸化和 c-Met 的酪氨酸磷酸化，IC50分别为 24 和 11 nM。Crizotinib 也是ROS1抑制剂。Crizotinib 具有有效的肿瘤生长抑制作用。 |
| IC50和靶点: | |
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Cui, J.J., Tran-Dubé, M., Shen, H., et al.Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK)J. Med. Chem.54(18),6342-6363(2011)
Tanizaki, J., Okamoto, I., Okamoto, K., et al.MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterationsJ. Thorac. Oncol.6(10),1624-1631(2011)
