Apcin
Cat. No.：YN290096
CAS No. ：300815-04-7
| 产品名称: | Apcin |
| CAS No.: | 300815-04-7 |
| Chemical Name: | [2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-carbamic acid, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester |
| Synonyms: | |
| 分子量: | 438.65 |
| 分子式: | C₁₃H₁₄Cl₃N₇O₄ |
| SMILES: | O=C(OCCN1C([N+]([O-])=O)=CN=C1C)NC(NC2=NC=CC=N2)C(Cl)(Cl)Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Apcin 是 Cdc20 的配体，是一种有效的，竞争性后期促进复合物/环体 (APC/C(Cdc20)) E3 连接酶活性抑制剂。Apcin 通过与 Cdc20 结合并阻止底物识别来竞争性抑制 APC/C 依赖性泛素化。Apcin 占据 WD40 结构域侧面的 D-box 结合口袋，并可以延长有丝分裂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Sackton, K.L., Dimova, N., Zeng, X., et al.Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/CNature514(7524),646-649(2014)
Lub, S., Maes, A., De Veirman, K., et al.Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cellsOncotarget7(4),4062-4076(2016)
