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TAME hydrochloride

Cat. No.:YN290247

  • CAS No. :1784-03-8

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    • 产品名称: TAME hydrochloride
      CAS No.: 1784-03-8
      Chemical Name: N2-[(4-methylphenyl)sulfonyl]-L-arginine, methyl ester, monohydrochloride
      Synonyms:Tos-Arg-OMe HCl,NA-P-甲苯磺酰-L-精氨酸甲酯盐酸盐,TOS-ARG-OME hydrochloride
      分子量:378.87
      分子式:C₁₄H₂₃ClN₄O₄S
      SMILES:CC1=CC=C(C=C1)S(N[C@H](C(OC)=O)CCCNC(N)=N)(=O)=O.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: TAME hydrochloride 是后期促进复合体(APC/C 或 APC)的抑制剂,它与 APC/C 结合并阻止其通过 Cdc20 和 Cdh1 活化,产生有丝分裂阻滞。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Hummel, B.C.A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombinCan. J. Biochem. Physiol.37,1393-1399(1959)

      Matsuda, Y., Miyazaki, K., Moriya, H., et al.Purification and characterization of human urinary kallikreinsJ. Biochem.80(4),671-679(1976)

      Esmon, C.T., Esmon, N.L., and Harris, K.W.Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activationJ. Biol. Chem.257(14),7944-7947(1982)

      Morgado-Díaz, J.A., da Silvia-Lopez, R.E., Alves, C.R., et al.Subcellular localization of an intracellular serine protease of 68 kDa in Leishmania (Leishmania) amazonensis promastigotesMem. Inst. Oswaldo Cruz100(4),377-383(2005)

      Zeng, X., Sigoillot, F., Gaur, S., et al.Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damageCancer Cell18(4),382-395(2010)

      Zeng, X., and King, R.W.An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitinationNat. Chem. Biol.8(4),383-392(2012)

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