AZD0156
Cat. No.：YN420001
CAS No. ：1821428-35-6
| 产品名称: | AZD0156 |
| CAS No.: | 1821428-35-6 |
| Chemical Name: | 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-2H-imidazo[4,5-c]quinolin-2-one |
| Synonyms: | AZ0156,AZ 0156 |
| 分子量: | 461.56 |
| 分子式: | C₂₆H₃₁N₅O₃ |
| SMILES: | O=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=C(OCCCN(C)C)N=C5)=CC=C4N=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD0156 是一种有效的，选择性的和口服活性的ATM抑制剂，IC50为 0.58 nM。AZD0156 抑制ATM介导的信号转导，防止 DNA 损伤检查点激活，破坏 DNA 损伤修复，并诱导肿瘤细胞凋亡 (apoptosis)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Pike, K.G., Barlaam, B., Cadogan, E., et al.The identification of potent, selective, and orally available inhibitors of ataxia telangiectasia mutated (ATM) kinase: The discovery of AZD0156 (8-{6-[3-(dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one)J. Med. Chem.61(9),3823-3841(2018)
