AZ32
Cat. No.：YN420086
CAS No. ：2288709-96-4
规格
价格(RMB)
库存
| 产品名称: | AZ32 |
| CAS No.: | 2288709-96-4 |
| Chemical Name: | N-methyl-4-(6-phenylimidazo[1,2-a]pyrazin-3-yl)-benzamide |
| Synonyms: | AZ32,AZ 32, AZ-32 |
| 分子量: | 328.37 |
| 分子式: | C₂₀H₁₆N₄O |
| SMILES: | O=C(NC)C(C=C1)=CC=C1C2=CN=C3C=NC(C4=CC=CC=C4)=CN32 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZ32 是一种口服可利用的，可穿透血脑屏障的ATM抑制剂，IC50<6.2 nM。在细胞中抑制 ATM，IC50为 0.31 μM。 |
| IC50和靶点: | [{name:"ATM:6.2 nM (IC50)"},{name: "ATM:0.31 μM (IC50, in cell)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Karlin, J., Allen, J., Ahmad, S.F., et al.Orally bioavailable and blood-brain barrier-penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in miceMol. Cancer Ther.17(8),1637-1647(2018)
