VE-821
Cat. No.：YN420194
CAS No. ：1232410-49-9
规格
价格(RMB)
库存
| 产品名称: | VE-821 |
| CAS No.: | 1232410-49-9 |
| Chemical Name: | 3-amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide |
| Synonyms: | ATR Inhibitor IV |
| 分子量: | 368.41 |
| 分子式: | C₁₈H₁₆N₄O₃S |
| SMILES: | O=C(NC1=CC=CC=C1)C2=NC(C3=CC=C(C=C3)S(=O)(C)=O)=CN=C2N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VE-821 是一种有效的 ATP 竞争性的ATR抑制剂，Ki/IC50为 13 nM/26 nM。 |
| IC50和靶点: | [{name:"ATR:13 nM (Ki)"},{name: "ATM:16 μM (Ki)"},{name: "DNA-PK:2.2 μM (Ki)"},{name: "PI3Kγ:3.9 μM (Ki)"}] |
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Reaper, P.M., Griffiths, M.R., Long, J.M., et al.Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATRNat. Chem. Biol.7(7),428-430(2011)
Pires, I.M., Olcina, M.M., Anbalagan, S., et al.Targeting radiation-resistant hypoxic tumour cells through ATR inhibitionBr. J. Cancer107,291-299(2012)
Prevo, R., Fokas, E., Reaper, P.M., et al.The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapyCancer Biol. Ther.13(11),1072-1081(2012)
Salovská, B., Fabrik, I., Durisová, K., et al.Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): Phosphoproteomic analysisInt. J. Mol. Sci.15,12007-12026(2014)
Huntoon, C.J., Flatten, K.S., Wahner Hendrickson, A.E., et al.ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA statusCancer Res.73(12),3683-3691(2013)
Flynn, R.L., Cox, K.E., Jeitany, M., et al.Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitorsScience347(6219),273-277(2015)
