ETP-46464
Cat. No.：YN420219
CAS No. ：1345675-02-6
规格
价格(RMB)
库存
| 产品名称: | ETP-46464 |
| CAS No.: | 1345675-02-6 |
| Chemical Name: | α,α-dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile |
| Synonyms: | ETP-46464;2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2,4-dihydro-1H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl)propanenitrile;2-methyl-2-[4-(2-oxo-9-quinolin-3-yl-4H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl]propanenitrile;ETP46464;4-[4-(1-Isocyano-1-methyl-ethyl) |
| 分子量: | 470.52 |
| 分子式: | C₃₀H₂₂N₄O₂ |
| SMILES: | O=C1N(C2=CC=C(C(C)(C#N)C)C=C2)C3=C4C(C=CC(C5=CN=C(C=CC=C6)C6=C5)=C4)=NC=C3CO1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ETP-46464 是一种有效的mTOR和ATR抑制剂，IC50分别为 0.6 和 14 nM。 |
| IC50和靶点: | [{name:"mTOR:0.6 nM (IC50)"},{name: "ATR:14 nM (IC50)"},{name: "ATM:545 nM (IC50)"},{name: "DNA-PK:36 nM (IC50)"},{name: "PI3Kα:170 nM (IC50)"}] |
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| Solvent & Solubility: |
Toledo, L.I., Murga, M., Zur, R., et al.A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutationsNat. Struct. Mol. Biol.18(6),721-727(2011)
