AZ20
Cat. No.：YN420220
CAS No. ：1233339-22-4
规格
价格(RMB)
库存
| 产品名称: | AZ20 |
| CAS No.: | 1233339-22-4 |
| Chemical Name: | 4-[4-[(3R)-3-methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole |
| Synonyms: | AZ-20; AZ 20, |
| 分子量: | 412.51 |
| 分子式: | C₂₁H₂₄N₄O₃S |
| SMILES: | O=S(C1(C2=CC(N3[C@H](C)COCC3)=NC(C4=CC=CC5=C4C=CN5)=N2)CC1)(C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZ20 是一种有效的，选择性的ATR抑制剂，IC50值为 5 nM；同时可抑制mTOR活性，IC50值为 38 nM。 |
| IC50和靶点: | [{name:"ATR:5 nM (IC50)"},{name: "mTOR:38 nM (IC50)"},{name: "PI3Kα:13000 nM (IC50)"}] |
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| Solvent & Solubility: |
Foote, K.M., Blades, K., Cronin, A., et al.Discovery of 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activityJ. Med. Chem.56(5),2125-2138(2013)
