Apoptolidin
Cat. No.：YN360368
CAS No. ：194874-06-1
| 产品名称: | Apoptolidin |
| CAS No.: | 194874-06-1 |
| Chemical Name: | (1R)-O-2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl-(1→4)-O-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→8)-3,5,7-trideoxy-1-C-[(2S,4S,5S,8E,10E,12R,13R,14E,16E,18E)-12-[(6-deoxy-4-O-methyl-α-L-glucopyranosyl)oxy]-5-hydroxy-4-methoxy-9,13,15,17 |
| Synonyms: | |
| 分子量: | 1129.37 |
| 分子式: | C₅₈H₉₆O₂₁ |
| SMILES: | O[C@H]([C@](OC(/C(C)=C/C(C)=C/C(C)=C/[C@H]1C)=O)([H])C[C@@H]([C@H](CC/C=C(/C=C/[C@H]1O[C@H](O[C@H]2C)[C@H]([C@@H]([C@H]2OC)O)O)C)O)OC)[C@](O[C@@H]([C@@H]3C)C[C@H](COC)O[C@H](O[C@H]4C)C[C@](O)([C@H]4O[C@H](O[C@@H]5C)C[C@H]([C@@H]5O)OC)C)([C@@H]([C@H]3O)C)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Apoptolidin 是从Nocardiopsis细菌中分离得到的一种聚酮类化合物。Apoptolidin 是一种选择性线粒体F1FOATPase抑制剂。Apoptolidin 是一种凋亡 (apoptosis)诱导剂，可诱导腺病毒型 12 癌基因(包括ElA) (IC50=10-17 ng/ml) 转化的细胞凋亡，但不诱导正常细胞的凋亡。 |
| IC50和靶点: | |
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Kim, J.W., Adachi, H., Shin-Ya, K., et al.Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis spJ. Antibiot. (Tokyo)50(7),628-630(1997)
Salomon, A.R., Voehringer, D.W., Herzenberg, L.A., et al.Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F0F1-ATPaseProc. Natl. Acad. Sci. USA97(26),14766-14771(2000)
Salomon, A.R., Voehringer, D.W., Herzenberg, L.A., et al.Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPaseChem. Biol.8,71-80(2001)
