Oligomycin A
Cat. No.：YN360579
| 产品名称: | Oligomycin A |
| CAS No.: | 579-13-5 |
| Chemical Name: | (1S,2'R,4E,5'R,6R,6'S,7S,8R,10S,11S,12R,14S,15R,16S,18E,20E,22S,25R,28R,29S)-22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(1Z)-2-hydroxy-1-propen-1-yl]-5',6,8,10,12,14,16,28,29-nonamethyl-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-trie |
| Synonyms: | MCH 32 |
| 分子量: | 791.06 |
| 分子式: | C₄₅H₇₄O₁₁ |
| SMILES: | O=C(/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@@H]1C)=O)O[C@@]([C@@H]2C)([H])[C@H](C)[C@@]3(CC[C@H](C)[C@H](C[C@H](O)C)O3)O[C@@]2([H])CC[C@@H](CC)/C=C/C=C/C[C@@H](C)[C@H](O)[C@@](C)(O)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Oligomycin A 是从链霉菌属中得到的一种线粒体F0F1-ATPase抑制剂，Ki值为 1 μM；Oligomycin A 具有抗真菌的功能。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Salomon, A.R., Voehringer, D.W., Herzenberg, L.A., et al.Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPaseChem. Biol.8,71-80(2001)
Shin, Y.K., Yoo, B.C., Chang, H.J., et al.Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistanceCancer Res.65(8),3162-3170(2005)
Laatsch, H., Kellner, M., Wolf, G., et al.Oligomycin F, a new immunosuppressive homologue of oligomycin AJ. Antibiot. (Tokyo)46(9),1334-1341(1993)
Zu, Y., Zhao, Q., Zhao, X., et al.Process optimization of the preparation of oligomycin-loaded folate-conjugated chitosan nanoparticles as a tumor-targeted drug delivery system using a two-level factorial design methodInt. J. Nanomedicine6,3429-3441(2011)
