AIM-100
Cat. No.：YN440310
CAS No. ：873305-35-2
规格
价格(RMB)
库存
| 产品名称: | AIM-100 |
| CAS No.: | 873305-35-2 |
| Chemical Name: | 5,6-diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]-furo[2,3-d]pyrimidin-4-amine |
| Synonyms: | AIM100 |
| 分子量: | 371.43 |
| 分子式: | C₂₃H₂₁N₃O₂ |
| SMILES: | C1(C2=C(C3=CC=CC=C3)OC4=C2C(NC[C@@H]5CCCO5)=NC=N4)=CC=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AIM-100 是一种有效的选择性Ack1抑制剂，IC50为 21.58 nM。AIM-100 还抑制 Tyr267磷酸化，但不抑制其他激酶，包括 PI3K 和 AKT 亚家族成员。AIM-100 具有抗癌作用。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Mahajan, K., Coppola, D., Rawal, B., et al.Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancerJ. Biol. Chem.287(26),22112-22122(2012)
Mahajan, K., Challa, S., Coppola, D., et al.Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activityProstate70(12),1274-1285(2010)
