Capadenoson
Cat. No.：YN1570008
CAS No. ：544417-40-5
| 产品名称: | Capadenoson |
| CAS No.: | 544417-40-5 |
| Chemical Name: | 2-amino-6-[[[2-(4-chlorophenyl)-4-thiazolyl]methyl]thio]-4-[4-(2-hydroxyethoxy)phenyl]-3,5-pyridinedicarbonitrile |
| Synonyms: | BAY 68-4986 |
| 分子量: | 520.03 |
| 分子式: | C₂₅H₁₈ClN₅O₂S₂ |
| SMILES: | N#CC1=C(C2=CC=C(OCCO)C=C2)C(C#N)=C(SCC3=CSC(C4=CC=C(Cl)C=C4)=N3)N=C1N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Capadenoson 是一种选择性的腺苷-A1受体 (adenosine-A1 receptor) 激动剂。 |
| IC50和靶点: | |
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Baltos, J.-A., Vecchio, E.A., Harris, M.A., et al.Capadenoson, a clinically trialed partial adenosine A1 receptor agonist, can stimulate adenosine A2B receptor biased agonismBiochem. Pharmacol.135,79-89(2017)
Meibom, D., Albrecht-Küpper, B., Diedrichs, N., et al.Neladenoson bialanate hydrochloride: A prodrug of a partial adenosine A1 receptor agonist for the chronic treatment of heart diseasesChemMedChem12(10),728-737(2017)
Bott-Flugel, L., Bernshausen, A., Schneider, H., et al.Selective attenuation of norepinephrine release and stress-induced heart rate increase by partial adenosine A1 agonismPLoS One6(3),e18048(2011)
Sabbah, H.N., Gupta, R.C., Kohli, S., et al.Chronic therapy with a partial adenosine A1-receptor agonist improves left ventricular function and remodeling in dogs with advanced heart failureCirc. Heart Fail.6(3),563-561(2013)
