8-Cyclopentyl-1,3-dimethylxanthine
Cat. No.：YN1570016
| 产品名称: | 8-Cyclopentyl-1,3-dimethylxanthine |
| CAS No.: | 35873-49-5 |
| Chemical Name: | 8-cyclopentyl-3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione |
| Synonyms: | CPT,A1受体拮抗剂,CPT |
| 分子量: | 248.28 |
| 分子式: | C₁₂H₁₆N₄O₂ |
| SMILES: | O=C(N1C)N(C)C2=C(N=C(C3CCCC3)N2)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 8-Cyclopentyl-1,3-dimethylxanthine (Compound 2a) 是一种选择性的腺苷A1受体拮抗剂，对 A1 受体和 A2 受体的Ki值分别为 10.9 nM 和 1440 nM。 |
| IC50和靶点: | |
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Jacobson, K.A., Kiriasis, L., Barone, S., et al.Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptorsJ. Med. Chem.32(8),1873-1879(1989)
Gribkoff, V.K., Bauman, L.A., and VanderMaelen, C.P.The adenosine antagonist 8-cyclopentyltheophylline reduces the depression of hippocampal neuronal responses during hypoxiaBrain Res.512(2),353-357(1990)
Dragunow, M., and Robertson, H.A.8-Cyclopentyl 1,3-dimethylxanthine prolongs epileptic seizures in ratsBrain Res.417(2),377-379(1987)
Spealman, R.D.Psychomotor stimulant effects of methylxanthines in squirrel monkeys: Relation to adenosine antagonismPsychopharmacology (Berl.)95(1),19-24(1988)
