GS-6201
Cat. No.：YN1710001
CAS No. ：752222-83-6
| 产品名称: | GS-6201 |
| CAS No.: | 752222-83-6 |
| Chemical Name: | 3-ethyl-3,9-dihydro-1-propyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-1H-purine-2,6-dione |
| Synonyms: | CVT-6883 |
| 分子量: | 446.43 |
| 分子式: | C₂₁H₂₁F₃N₆O₂ |
| SMILES: | O=C(N1CCC)N(CC)C2=C(N=C(C3=CN(CC4=CC=CC(C(F)(F)F)=C4)N=C3)N2)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GS-6201 (CVT-6883) 是一种选择性的腺苷A2B受体拮抗剂。GS-6201 对人腺苷 A2B 受体具有高亲和力和选择性 (Ki=22 nM)。GS-6201 降低了小鼠急性心肌梗死 (AMI) 后心脏中 caspase-1 的活性，并减弱了心脏重塑。GS-6201 减弱了致敏小鼠 NECA，AMP 或变应原诱导的气道反应性。 |
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Elzein, E., Kalla, R.V., Li, X., et al.Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseasesJ. Med. Chem.51(7),2267-2278(2008)
Mustafa, S.J., Nadeem, A., Fan, M., et al.Effect of a specific and selective A2B adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthmaJ. Pharmacol. Exp. Ther.320(3),1246-1251(2007)
Zhang, H., Zhong, H., Everett, T.H., 4th, et al.Blockade of A2B adenosine receptor reduces left ventricular dysfunction and ventricular arrhythmias 1 week after myocardial infarction in the rat modelHeart Rhythm11(1),101-109(2014)
