BAY 60-6583
Cat. No.：YN1710005
CAS No. ：910487-58-0
| 产品名称: | BAY 60-6583 |
| CAS No.: | 910487-58-0 |
| Chemical Name: | 2-[[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide |
| Synonyms: | BAY606583 |
| 分子量: | 379.44 |
| 分子式: | C₁₉H₁₇N₅O₂S |
| SMILES: | O=C(N)CSC1=NC(N)=C(C#N)C(C2=CC=C(OCC3CC3)C=C2)=C1C#N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BAY 60-6583 是腺苷A2B受体的高效选择性激动剂， 对 A2B 受体 (EC50= 3 nM) 的选择性高于 A1，A2A 和 A3 受体。BAY 60-6583 可以与小鼠，兔和狗 A2BAR 结合，Ki值分别为 750 nM，340 nM 和 330 nM。BAY 60-6583 在心肌缺血模型中具有心脏保护作用。 |
| IC50和靶点: | |
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Baraldi, P.G., Tabrizi, M.A., Fruttarolo, F., et al.Recent improvements in the development of A2B adenosine receptor agonistsPurinergic Signal.5(1),3-19(2009)
van der Hoeven, D., Wan, T.C., Gizewski, E.T., et al.A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophilsJ. Pharmacol. Exp. Ther.338(3),1004-1012(2011)
Johnston-Cox, H., Koupenova, M., Yang, D., et al.The A2b adenosine receptor modulates glucose homeostasis and obesityPLoS One7(7),1-9(2012)
