AB928
Cat. No.：YN1710018
CAS No. ：2239273-34-6
| 产品名称: | AB928 |
| CAS No.: | 2239273-34-6 |
| Chemical Name: | 3-[2-amino-6-[1-[[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl]-1H-1,2,3-triazol-4-yl]-4-pyrimidinyl]-2-methyl-benzonitrile |
| Synonyms: | A2aR/A2bR antagonist-1 |
| 分子量: | 426.47 |
| 分子式: | C₂₃H₂₂N₈O |
| SMILES: | N#CC1=CC=CC(C2=NC(N)=NC(C3=CN(CC4=NC(C(C)(O)C)=CC=C4)N=N3)=C2)=C1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AB928 是一种具有口服活性、选择性的腺苷受体(A2aR/A2bR)双拮抗剂。AB928 减轻腺苷介导的免疫抑制。AB928 具有免疫调节和抗肿瘤活性。 |
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Seitz, L., Jin, L., Leleti, M., et al.Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteersInvest. New Drugs37(4),711-721(2019)
Walters, M.J., Piovesan, D., Tan, J., et al.Abstract 5556: Combining adenosine receptor inhibition with AB928 and chemotherapy results in greater immune activation and tumor controlCancer Res.78(13 Suppl.),(2018)
DiRenzo, D., Piovesan, D., Tan, J., et al.Abstract A162: AB928, a dual antagonist of the A2aR and A2bR adenosine receptors, relieves adenosine-mediated immune suppressionCancer Immunol. Res.7(2 Suppl.),(2019)
