MRS 1754
Cat. No.：YN1710027
CAS No. ：264622-58-4
| 产品名称: | MRS 1754 |
| CAS No.: | 264622-58-4 |
| Chemical Name: | N-(4-cyanophenyl)-2-[4-(2,3,6,9-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide |
| Synonyms: | MRS1754,MRS-1754,MRS 1754 |
| 分子量: | 486.52 |
| 分子式: | C₂₆H₂₆N₆O₄ |
| SMILES: | O=C(NC1=CC=C(C#N)C=C1)COC2=CC=C(C(N3)=NC(N(CCC)C(N4CCC)=O)=C3C4=O)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MRS 1754 是一种选择性 A2B腺苷受体拮抗剂，对人和大鼠的 A1和 A3受体具有非常低的亲和力。 |
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Kim, Y.-C., Ji, X.-d., Melman, N., et al.Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptorsJ. Med. Chem.43(6),1165-1172(2000)
Belikoff, B.G., Hatfield, S., Georgiev, P., et al.A2B adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in miceJ. Immunol.186(4),2444-2453(2011)
Wei, W., Du, C., Lv, J., et al.Blocking A2B adenosine receptor alleviates pathogenesis of experimental autoimmune encephalomyelitis via inhibition of IL-6 production and Th17 differentiationJ. Immunol.190(1),138-146(2013)
