Cirazoline hydrochloride
Cat. No.：YN1730009
| 产品名称: | Cirazoline hydrochloride |
| CAS No.: | 40600-13-3 |
| Chemical Name: | 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole, monohydrochloride |
| Synonyms: | LD 3098 hydrochloride |
| 分子量: | 252.74 |
| 分子式: | C₁₃H₁₇ClN₂O |
| SMILES: | [H]Cl.C1(COC2=CC=CC=C2C3CC3)=NCCN1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cirazoline hydrochloride (LD 3098 hydrochloride) 是一种强有力的竞争性 α1A 肾上腺素受体 (α1A-AR) 的全激动剂，α1B-AR 和 α1D-AR 的部分激动剂，Ki值分别为 120 nM， 960 nM 和 660 nM。 |
| IC50和靶点: | |
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Horie, K., Obika, K., Foglar, R., et al.Selectivity of the imidazoline α-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned α1-adrenoceptor subtypesBr. J. Pharmacol.116(1),1611-1618(1995)
Ruffolo, R.R., Jr., and Waddell, J.E.Receptor interactions of imidazolines: α-Adrenoceptors of rat and rabbit aortae differentiated by relative potencies, affinities and efficacies of imidazoline agonistsBr. J. Pharmacol.77(1),169-176(1982)
Bousquet, P., Feldman, J., and Schwartz, J.Central cardiovascular effects of alpha adrenergic drugs: Differences between catecholamines and imidazolinesJ. Pharmacol. Exp. Ther.2301(1),232-236(1984)
Doze, V.A., Papay, R.S., Goldenstein, B.L., et al.Long-term α1A-adrenergic receptor stimulation improves synaptic plasticity, cognitive function, mood, and longevityMol. Pharmacol.80(4),747-758(2011)
Arnsten, A.F.T., and Jentsch, J.D.The alpha-1 adrenergic agonist, cirazoline, impairs spatial working memory performance in aged monkeysPharmacol. Biochem. Behav.58(1),55-59(1997)
