Istradefylline
Cat. No.：YN1730028
CAS No. ：155270-99-8
| 产品名称: | Istradefylline |
| CAS No.: | 155270-99-8 |
| Chemical Name: | 8-[(1E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione |
| Synonyms: | 伊曲茶碱; KW-6002 |
| 分子量: | 384.43 |
| 分子式: | C₂₀H₂₄N₄O₄ |
| SMILES: | O=C1C2=C(N=C(/C=C/C3=CC(OC)=C(OC)C=C3)N2C)N(CC)C(N1CC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Istradefylline 是一种有效的，选择性的，可口服的adenosine A2A receptor拮抗剂，在帕金森疾病模型试验中，Ki值为 2.2 nM。 |
| IC50和靶点: | |
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Shimada, J., Nobuaki, K., Nonaka, H., et al.Adenosine A2A antagonists with potent anti-cataleptic activityBioorg. Med. Chem. Lett.7(18),2349-2352(1997)
Kanda, T., Jackson, M.J., Smith, L.A., et al.Adenosine A2A antagonist: A novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeysAnn. Neurol.43(4),507-513(1998)
Ko, W.K.D., Camus, S.M., Li, Q., et al.An evaluation of istradefylline treatment on Parkinsonian motor and cognitive deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque modelsNeuropharmacology100(Pt. A),48-58(2016)
