Preladenant
Cat. No.：YN1730029
CAS No. ：377727-87-2
| 产品名称: | Preladenant |
| CAS No.: | 377727-87-2 |
| Chemical Name: | 2-(2-furanyl)-7-[2-[4-[4-(2-methoxyethoxy)phenyl]-1-piperazinyl]ethyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine |
| Synonyms: | SCH-420814 |
| 分子量: | 503.56 |
| 分子式: | C₂₅H₂₉N₉O₃ |
| SMILES: | NC1=NC(N(CCN2CCN(C3=CC=C(OCCOC)C=C3)CC2)N=C4)=C4C5=NC(C6=CC=CO6)=NN51 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Preladenant 是一种有效，竞争性的人腺苷A2A受体拮抗剂，Ki为 1.1 nM，比其他腺苷受体选择性高100倍以上。 |
| IC50和靶点: | |
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Neustadt, B.R., Hao, J., Lindo, N., et al.Potent, selective, and orally active adenosine A2A receptor antagonists: Arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidinesBioorg. Med. Chem. Lett.17(5),1376-1380(2007)
Pinna, A., Kin, W., Costa, G., et al.Antidyskinetic effect of A2A and 5HT1A/1B receptor ligands in two animal models of Parkinson's diseaseMov. Disord.31(4),501-511(2016)
