Rolofylline
Cat. No.：YN1730033
CAS No. ：136199-02-5
| 产品名称: | Rolofylline |
| CAS No.: | 136199-02-5 |
| Chemical Name: | 8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-1,3-dipropyl-1H-purine-2,6-dione |
| Synonyms: | KW-3902 |
| 分子量: | 356.46 |
| 分子式: | C₂₀H₂₈N₄O₂ |
| SMILES: | O=C(N1CCC)N(CCC)C2=C(N=C(C34CC(C5)CC3CC5C4)N2)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rolofylline (KW-3902) 是一种有效的选择性adenosine A1 receptor拮抗剂，目前正在开发用于急性充血性心力衰竭和肾功能损害的演技。_x000D_ Rolofylline 主要通过细胞色素 P450 (CYP450) 代谢为药理学活性的 M1-反式和 M1-顺式代谢物。_x000D_ Rolofylline 可以减轻突触前功能障碍，恢复体外神经元活动以及树突棘水平，可用于对抗Tau-诱导的神经退行性疾病相关的代谢减退以及神经功能障碍。 |
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Shimada, J., Suzuki, F., Nonaka, H., et al.8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptorsJ. Med. Chem.35(5),924-930(1992)
Nonaka, H., Ichimura, M., Takeda, M., et al.KW-3902, a selective high affinity antagonist for adenosine A1 receptorsBr. J. Pharmacol.117(8),1645-1652(1996)
Takeda, M., Narikawa, S., Hosoyamada, M., et al.Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transportersEur. J. Pharmacol.419(2-3),113-120(2001)
Nishiyama, A., Miyatake, A., Aki, Y., et al.Adenosine A1 receptor antagonist KW-3902 prevents hypoxia-induced renal vasoconstrictionJ. Pharmacol. Exp. Ther.291(3),988-993(1999)
