Tozadenant
Cat. No.：YN1730034
CAS No. ：870070-55-6
| 产品名称: | Tozadenant |
| CAS No.: | 870070-55-6 |
| Chemical Name: | 4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide |
| Synonyms: | SYN115 |
| 分子量: | 406.50 |
| 分子式: | C₁₉H₂₆N₄O₄S |
| SMILES: | O=C(NC1=NC2=C(C=CC(N3CCOCC3)=C2S1)OC)N4CCC(O)(CC4)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tozadenant 是adenosine A2A 受体拮抗剂，作用于人类和恒河猴的 adenosine A2A 受体，Ki值分别为 11.5 nM 和 6 nM。 |
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Barret, O., Hannestad, J., Alagille, D., et al.Adenosine 2A receptor occupancy by tozadenant and preladenant in rhesus monkeysJ. Nucl. Med.55(10),1712-1718(2014)
Michel, A., Downey, P., Van Damme, X., et al.Behavioural assessment of the A2a/NR2B combination in the unilateral 6-OHDA-lesioned rat model: A new method to examine the therapeutic potential of non-dopaminergic drugsPLoS One10(8),e0135949(2015)
Michel, A., Nicolas, J.M., Rose, S., et al.Antiparkinsonian effects of the "Radiprodil and Tozadenant" combination in MPTP-treated marmosetsPLoS One12(8),e0182887(2017)
