ZM241385
Cat. No.：YN1730084
CAS No. ：139180-30-6
| 产品名称: | ZM241385 |
| CAS No.: | 139180-30-6 |
| Chemical Name: | 4-[2-[[7-amino-2-(2-furanyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]-phenol |
| Synonyms: | ZM 241385, ZM241385, ZM-241385 |
| 分子量: | 337.34 |
| 分子式: | C₁₆H₁₅N₇O₂ |
| SMILES: | OC1=CC=C(CCNC2=NC3=NC(C4=CC=CO4)=NN3C(N)=N2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ZM241385 是一种有效的，高亲和力的选择性的腺苷A2AR拮抗剂，其Ki值为 1.4 nM。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Poucher, S.M., Keddie, J.R., Singh, P., et al.The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonistBr. J. Pharmacol.115(6),1096-1102(1995)
Linden, J., Thai, T., Figler, H., et al.Characterization of human A2B adenosine receptors: Radioligand binding, western blotting, and coupling to Gq in human embryonic kidney 293 cells and HMC-1 mast cellsMol. Pharmacol.56(4),705-713(1999)
Keddie, J.R., Poucher, S.M., Shaw, G.R., et al.In vivo characterisation of ZM 241385, a selective adenosine A2A receptor antagonistEur. J. Pharmacol.301(1-3),107-113(1996)
Poucher, S.M., Keddie, J.R., Brooks, R., et al.Pharmacodynamics of ZM 241385, a potent A2a adenosine receptor antagonist, after enteric administration in rat, cat and dogJ. Pharm. Pharmacol.48(6),601-606(1996)
Li, Q., Ye, K., Blad, C.C., et al.ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptorJ. Pharmacol. Exp. Ther.320(2),637-645(2007)
