NKH477
Cat. No.：YN320245
CAS No. ：138605-00-2
| 产品名称: | NKH477 |
| CAS No.: | 138605-00-2 |
| Chemical Name: | (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-β-alanine, N,N-dimethyl-oxo-1H-naphtho[2,1-b]pyran-6-yl ester, monohydrochloride |
| Synonyms: | Colforsin dapropate hydrochloride |
| 分子量: | 546.09 |
| 分子式: | C₂₇H₄₄ClNO₈ |
| SMILES: | O[C@@]12[C@@]3([C@@](C(C)(CC[C@@H]3O)C)([H])[C@H](OC(CCN(C)C)=O)[C@H](OC(C)=O)[C@]1(O[C@](C=C)(C)CC2=O)C)C.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NKH477 (Colforsin dapropate hydrochloride) 是一种新型水溶性毛喉素衍生物，主要通过对舒张性心脏功能的有益作用来改善心力衰竭。 NKH477 直接激活腺苷酸环化酶 (adenylate cyclase)的催化单元并增加细胞内 cAMP。 NKH477 在体内抗增殖作用，可以抑制大鼠原位肺同种异体移植物的急性排斥。 |
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Hosono, M., Takahira, T., Fujita, A., et al.Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel water-soluble forskolin derivativeJ. Biomed. Sci.19(4),625-634(1992)
Sanbe, A., and Takeo, S.Effects of NKH477, a water-soluble forskolin derivative, on cardiac function in rats with chronic heart failure after myocardial infarctionJ. Pharmacol. Exp. Ther.274(1),120-126(1995)
Satake, K., Takagi, K., Kodama, I., et al.Relaxant effects of NKH477, a new water-soluble forskolin derivative, on guinea-pig tracheal smooth muscle: The role of Ca2+-activated K+ channelsBr. J. Pharmacol.123(4),753-761(1998)
Toya, Y., Schwencke, C., and Ishikawa, Y.Forskolin derivatives with increased selectivity for cardiac adenylyl cyclaseJ. Mol. Cell. Cardiol.30(1),97-108(1998)
