Forskolin
Cat. No.：YN320969
CAS No. ：66575-29-9
| 产品名称: | Forskolin |
| CAS No.: | 66575-29-9 |
| Chemical Name: | 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-1H-naphtho[2,1-b]pyran-1-one |
| Synonyms: | 毛喉素; Coleonol; Colforsin |
| 分子量: | 410.50 |
| 分子式: | C₂₂H₃₄O₇ |
| SMILES: | O=C1[C@@]2(O)[C@]([C@@H](OC(C)=O)[C@@H](O)[C@@]3([H])C(C)(C)CC[C@H](O)[C@@]32C)(C)O[C@@](C)(C=C)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Forskolin (Coleonol) 是一种有效的腺苷酸环化酶 (adenylate cyclase) 激活剂，对于 I 型腺苷酸环化酶，IC50为 41 nM，EC50为 0.5 μM。Forskolin 也是一种细胞内cAMP形成的诱导剂。Forskolin 诱导多种细胞类型的分化并激活孕烷 X 受体 (PXR) 和FXR。Forskolin 对心脏产生正性肌力作用，并具有血小板抗凝集和降压作用。Forskolin 也可诱导细胞自噬 (autophagy)。 |
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Robbins, J.D., Boring, D.L., Tang, W.J., et al.Forskolin carbamates: Binding and activation studies with type I adenylyl cyclaseJ. Med. Chem.39(14),2745-2752(1996)
Insel, P.A., and Ostrom, R.S.Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signalingCell Mol. Neurobiol.23(3),305-314(2003)
