Silodosin
Cat. No.：YN320113
CAS No. ：160970-54-7
| 产品名称: | Silodosin |
| CAS No.: | 160970-54-7 |
| Chemical Name: | 2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide |
| Synonyms: | 西洛多辛; KAD 3213; KMD 3213 |
| 分子量: | 495.53 |
| 分子式: | C₂₅H₃₂F₃N₃O₄ |
| SMILES: | O=C(N)C1=CC(C[C@@H](C)NCCOC2=CC=CC=C2OCC(F)(F)F)=CC3=C1N(CC3)CCCO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Silodosin (KAD 3213; KMD 3213) 是一个强效的、有选择性的、口服活性的α1A-adrenergic receptor (α1A-AR)阻滞剂。Silodosin 对 α1A-AR 表现出高度的亲和力 (Ki=0.036 nM)，是 α1B-AR 和 α1D-AR 亲和力的 162 和 50 倍，Ki值分别为 21 nM 和 2.0 nM。Silodosin 是一种有效且耐受性良好的试剂，可用于 LUTS/BPH 的研究。 |
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Moriyama, N., Akiyama, K., Murata, S., et al.KMD-3213, a novel α1A-adrenoceptor antagonist, potently inhibits the functional α1-adrenoceptor in human prostateEur. J. Pharmacol.331(1),39-42(1997)
Li, M.Y., Tsai, K.C., and Xia, L.Pharmacophore identification of α1A-adrenoceptor antagonistsBioorg. Med. Chem. Lett.15(3),657-664(2005)
Akiyama, K., Hora, M., Tatemichi, S., et al.KMD-3213, a uroselective and long-acting α1a-adrenoceptor antagonist, tested in a novel rat modelJ. Pharmacol. Exp. Ther.291(1),81-91(1999)
Ding, H., Du, W., Hou, Z.Z., et al.Silodosin is effective for treatment of LUTS in men with BPH: A systematic reviewAsian J. Androl.15(1),121-128(2013)
Yoshida, M., Kudoh, J., Homma, Y., et al.Safety and efficacy of silodosin for the treatment of benign prostatic hyperplasiaClin. Interv. Aging6,161-172(2011)
