SR59230A hydrochloride
Cat. No.：YN320247
CAS No. ：1135278-41-9
| 产品名称: | SR59230A hydrochloride |
| CAS No.: | 1135278-41-9 |
| Chemical Name: | (2S)-1-(2-ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-2-propanol, monohydrochloride |
| Synonyms: | SR 59230A HCl; SR59230A HCl; SR 59230A; SR59230A; SR-59230A. |
| 分子量: | 361.91 |
| 分子式: | C₂₁H₂₈ClNO₂ |
| SMILES: | O[C@@H](CN[C@H]1CCCC2=C1C=CC=C2)COC3=CC=CC=C3CC.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SR59230A hydrochloride 是一种有效，选择性的，可透过血脑屏障的 β3-肾上腺素能受体 (β3-adrenergic receptor) 拮抗剂，对 β3，β1 和 β2 受体的IC50分别为 40、408 和 648 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Manara, L., Badone, D., Baroni, M., et al.Functional identification of rat atypical β-adrenoceptors by the first β3-selective antagonists, aryloxypropanolaminotetralinsBr. J. Pharmacol.117(3),435-442(1996)
Hoffman, C., Leitz, M.R., Oberdorf-Maass, S., et al.Comparative pharmacology of human β-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cellsNaunyn-Schmiedeberg's Arch. Pharmacol.369(2),151-159(2004)
Bexis, S., and Docherty, J.R.Role of α1- and β3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouseBr. J. Pharmacol.158(1),259-266(2009)
Mizuno, K., Kanda, Y., Kuroki, Y., et al.Stimulation of β3-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytesBr. J. Pharmacol.135(4),951-960(2002)
Gan, R.T., Li, W.M., Xiu, C.H., et al.Chronic blocking of β3-adrenoceptor ameliorates cardiac function in rat model of heart failureChin. Med. J. (Engl.)120(24),2250-2255(2007)
