Amibegron hydrochloride
Cat. No.：YN320248
| 产品名称: | Amibegron hydrochloride |
| CAS No.: | 121524-09-2 |
| Chemical Name: | [[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-acetic acid, ethyl ester, monohydrochloride |
| Synonyms: | SR 58611A |
| 分子量: | 440.36 |
| 分子式: | C₂₂H₂₇Cl₂NO₄ |
| SMILES: | O=C(OCC)COC1=CC=C2CC[C@H](NC[C@@H](C3=CC=CC(Cl)=C3)O)CC2=C1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Amibegron hydrochloride 是一种选择性的β3-adrenoceptor激动剂，对大鼠结肠β-adrenoceptor的EC50值为 3.5 nM；Amibegron hydrochloride 具有抗焦虑和抗抑郁的活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Bianchetti, A., and Manara, L.In vitro inhibition of intestinal motility by phenylethanolaminotetralines: Evidence of atypical β-adrenoceptors in rat colon.Br. J. Pharmacol.100(4),831-839(1990)
Nisoli, E., Tonello, C., and Carruba, M.O.SR 58611A: A novel thermogenic β-adrenoceptor agonistEur. J. Pharmacol.259(2),181-186(1994)
Simiand, J., Keane, P.E., Guitard, J., et al.Antidepressant profile in rodents of SR 58611A, a new selective agonist for atypical β-adrenoceptorsEur. J. Pharmacol.219(2),193-201(1992)
