CL 316243
Cat. No.：YN320504
| 产品名称: | CL 316243 |
| CAS No.: | 138908-40-4 |
| Chemical Name: | 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid, disodium salt |
| Synonyms: | CL316243 disodium |
| 分子量: | 465.79 |
| 分子式: | C₂₀H₁₈ClNNa₂O₇ |
| SMILES: | O=C(C1(C(O[Na])=O)OC2=CC=C(C[C@H](NC[C@@H](C3=CC=CC(Cl)=C3)O)C)C=C2O1)O[Na] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CL316243 是一种高效的选择性 β3-肾上腺素受体 (β3-adrenoceptor) 激动剂，EC50为 3 nM，但其对 β1/2-受体选择性却比较差。CL316243 是一种有效的脂肪细胞脂解刺激剂，可增加棕色脂肪组织的生热作用和代谢率。CL316243 具有有潜力用于肥胖症，糖尿病和尿失禁的相关研究。 |
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Bloom, J.D., Dutia, M.D., Johnson, B.D., et al.Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and antiobesity agentJ. Med. Chem.35(16),3081-3084(1992)
Baker, J.G.The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptorsBr. J. Pharmacol.144(3),317-322(2005)
Guerra, C., Koza, R.A., Yamashita, H., et al.Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposityJ. Clin. Invest.102(2),412-420(1998)
MacPherson, R.E.K., Castellani, L., Bueadoin, M.S., et al.Evidence for fatty acids mediating CL 316,243-induced reductions in blood glucose in miceAm. J. Physiol. Endocrinol. Metab.307(7),E563-E570(2014)
