Bevantolol hydrochloride
Cat. No.：YN320544
CAS No. ：42864-78-8
| 产品名称: | Bevantolol hydrochloride |
| CAS No.: | 42864-78-8 |
| Chemical Name: | 1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol, monohydrochloride |
| Synonyms: | NC-1400 hydrochloride |
| 分子量: | 381.89 |
| 分子式: | C₂₀H₂₈ClNO₄ |
| SMILES: | OC(CNCCC1=CC=C(C(OC)=C1)OC)COC2=CC=CC(C)=C2.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bevantolol hydrochloride 是一种选择性的 β1/α1-肾上腺素受体 (β1/α1-adrenergic receptor) 拮抗剂，在大鼠大脑皮层中的pKi值分别为 7.83、6.9。Bevantolol hydrochloride 是有效的Ca2+拮抗剂。 |
| IC50和靶点: | |
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Takita, M., Kigoshi, S., and Muramatsu, I.Selectivity of bevantolol hydrochloride towards ɑ and β-adrenoceptor subtypes in rat cerebral cortexJpn. J. Pharmacol.58(2),193-196(1992)
T., O., Kobayashi, T., Nishioka, K., et al.Ca2+-antagonistic action of bevantolol on hypothalamic neurons in vitro: Its comparison with those of other β-adrenoceptor antagonists, a local anesthetic and a Ca2+-antagonistBrain Res.706(2),289-292(1996)
Takayanagi, I., Kizawa, Y., Iwasaki, S., et al.(+/-)-1-[[2-(3,4-dimethoxphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol hydrochloride (bevantolol, NC-1400) as a β1-selective adrenoceptor blocker With ɑ1-adrenoceptor Blocking ActivityGen. Pharmacol.18(1),87-90(1987)
Takita, M., Kigoshi, S., and Muramatsu, I.Effects of bevantolol HCl on immobilization stress-induced hypertension and central β-adrenoceptors in ratsPharmacol. Biochem. Behav.45,623-627(1993)
