Atipamezole hydrochloride
Cat. No.：YN320584
| 产品名称: | Atipamezole hydrochloride |
| CAS No.: | 104075-48-1 |
| Chemical Name: | 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole, monohydrochloride |
| Synonyms: | 阿替美唑盐酸盐; MPV-1248 hydrochloride |
| 分子量: | 248.75 |
| 分子式: | C₁₄H₁₇ClN₂ |
| SMILES: | CCC1(C2=CN=CN2)CC3=C(C=CC=C3)C1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Atipamezole hydrochloride是合成的α2-肾上腺素受体拮抗剂,Ki值为1.6 nM。 |
| IC50和靶点: | |
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Vacher, B., Funes, P., Chopin, P., et al.Rigid analogues of the α2-adrenergic blocker atipamezole: Small changes, big consequencesJ. Med. Chem.53(19),6986-6995(2010)
Pertovaara, A., Haapalinna, A., Sirviö, J., et al.Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective α2-adrenoceptor antagonistCNS Drug Rev.11(3),273-288(2005)
Vainio, O., and Vähä-Vahe, T.Reversal of medetomidine sedation by atipamezole in dogsJ. Vet. Pharmacol. Ther.13(1),15-22(1990)
Lizarraga, I., and Chambers, J.P.Involvement of opioidergic and α2-adrenergic mechanisms in the central analgesic effects of non-steroidal anti-inflammatory drugs in sheepRes. Vet. Sci.80(2),194-200(2006)
Haapalinna, A., Leino, T., and Heinonen, E.The α2-adrenoceptor antagonist atipamezole potentiates anti-Parkinsonian effects and can reduce the adverse cardiovascular effects of dopaminergic drugs in ratsNaunyn Schmiedebergs Arch. Pharmacol.368(5),342-351(2003)
