Rauwolscine hydrochloride
Cat. No.：YN320632
| 产品名称: | Rauwolscine hydrochloride |
| CAS No.: | 6211-32-1 |
| Chemical Name: | (16β,17α,20α)-17-hydroxy-yohimban-16-carboxylic acid, methyl ester, monohydrochloride |
| Synonyms: | 萝芙素盐酸盐; α-Yohimbine hydrochloride; Corynanthidine hydrochloride; Isoyohimbine hydrochloride |
| 分子量: | 390.90 |
| 分子式: | C₂₁H₂₇ClN₂O₃ |
| SMILES: | [H]Cl.[H][C@]12C(NC3=C4C=CC=C3)=C4CCN1C[C@@]5([H])CC[C@H](O)[C@@H](C(OC)=O)[C@]5(C2)[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rauwolscine hydrochloride是高效，选择性的α2 adrenergic受体拮抗剂，Ki值为12 nM。 |
| IC50和靶点: | |
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Perry, B.D., and U'Prichard, D.C.[3H]rauwolscine (α-yohimbine): A specific antagonist radioligand for brain α2-adrenergic receptorsEur. J. Pharmacol.76(4),461-464(1981)
Kaumann, A.J.Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptorsNaunyn Schmiedebergs Arch. Pharmacol.323(2),149-154(1983)
Arthur, J.M., Casañas, S.J., and Raymond, J.R.Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptorsBiochem. Pharmacol.45(11),2337-2341(1993)
Wainscott, D.B., Sasso, D.A., Kursar, J.D., et al.[3H]Rauwolscine: An antagonist radioligand for the cloned human 5-hydroxytryptamine2B (5-HT2B) receptorNaunyn Schmiedebergs Arch. Pharmacol.357(1),17-24(1998)
Brede, M., Philipp, M., Knaus, A., et al.α2-adrenergic receptor subtypes - novel functions uncovered in gene-targeted mouse modelsBiology of the Cell96(5),343-348(2004)
Cottingham, C., and Wang, Q.α2 adrenergic receptor dysregulation in depressive disorders: Implications for the neurobiology of depression and antidepressant therapyNeurosci. Biobehav. Rev.36(10),2214-2225(2012)
