Pimozide
Cat. No.：YN320674
| 产品名称: | Pimozide |
| CAS No.: | 2062-78-4 |
| Chemical Name: | 1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one |
| Synonyms: | 匹莫齐特; R6238 |
| 分子量: | 461.55 |
| 分子式: | C₂₈H₂₉F₂N₃O |
| SMILES: | O=C1NC2=CC=CC=C2N1C3CCN(CCCC(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pimozide 是dopamine receptor的拮抗剂，对 dopamine D2，D3 和 D1 受体的Ki值分别为 1.4 nM，2.5 nM 和 588 nM，同时对α1-adrenoceptor也有较高亲和性，Ki值为 39 nM；Pimozide 也是STAT3和STAT5的抑制剂。 |
| IC50和靶点: | [{name:"Dopamine D2 receptor:1.4 nM (Ki)"},{name: "Dopamine D3 receptor:2.5 nM (Ki)"},{name: "Dopamine D1 receptor:588 nM (Ki)"},{name: "α1-adrenoceptor:39 nM (Ki)'}, 'STAT3', 'STAT5'] |
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Xenakis, S., and Sclafani, A.The effects of pimozide on the consumption of a palatable saccharin-glucose solution in the ratPharmacol. Biochem. Behav.15(3),435-442(1980)
Navarro, J.F., Velasco, R., and Manzaneque, J.M.Acute and subchronic effects of pimozide on isolation-induced aggression in male miceProg. Neuropsychopharmacol. Biol. Psychiatry24(1),131-142(2000)
