Pimozide D4
Cat. No.：YN320675
| 产品名称: | Pimozide D4 |
| CAS No.: | 1803193-57-8 |
| Chemical Name: | 1-[1-[4-(4-fluorophenyl)-4-(4-fluorophenyl-2,3,5,6-d4)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one |
| Synonyms: | R6238 D4 |
| 分子量: | 465.57 |
| 分子式: | C₂₈H₂₅D₄F₂N₃O |
| SMILES: | O=C1NC2=CC=CC=C2N1C3CCN(CCCC(C4=CC=C(F)C=C4)C5=C([2H])C([2H])=C(F)C([2H])=C5[2H])CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pimozide D4 (SKI-606 D8) 是 Pimozide 的氘代物。Pimozide 是dopamine receptor的拮抗剂，对dopamine D2，D3和D1受体的Ki值分别为 1.4 nM，2.5 nM 和 588 nM，同时对α1-adrenoceptor也有较高亲和性，Ki值为 39 nM；Pimozide 也是STAT3和STAT5的抑制剂。 |
| IC50和靶点: | [{name:"Dopamine D2 receptor:1.4 nM (Ki)"},{name: "opamine D3 receptor:2.5 nM (Ki)"},{name: "opamine D1 receptor:588 nM (Ki)"},{name: "α1-adrenoceptor:39 nM (Ki)'}, 'STAT3', 'STAT5'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Burstein, E.S., Ma, J., Wong, S., et al.Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: Identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonistJ. Pharmacol. Exp. Ther.315(3),1278-1287(2005)
Richelson, E., and Souder, T.Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compoundsLife Sci.68(1),29-39(2000)
Roufos, I., Hay, S., and Schwarz, R.D.A structure-activity relationship study of novel phenylacetamides which are sodium channel blockersJ. Med. Chem.39(7),1514-1520(1996)
Lau, J.F., Jeppesen, C.B., Rimvall, K., et al.Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amidesBioorg. Med. Chem. Lett.16(20),5303-5308(2006)
Xenakis, S., and Sclafani, A.The effects of pimozide on the consumption of a palatable saccharin-glucose solution in the ratPharmacol. Biochem. Behav.15(3),435-442(1980)
Navarro, J.F., Velasco, R., and Manzaneque, J.M.Acute and subchronic effects of pimozide on isolation-induced aggression in male miceProg. Neuropsychopharmacol. Biol. Psychiatry24(1),131-142(2000)
