YS-49
Cat. No.：YN320996
| 产品名称: | YS-49 |
| CAS No.: | 132836-42-1 |
| Chemical Name: | 1,2,3,4-tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol, monohydrobromide |
| Synonyms: | YS 49,Ys49 |
| 分子量: | 386.28 |
| 分子式: | C₂₀H₂₀BrNO₂ |
| SMILES: | OC1=CC2=C(C(CC3=C4C=CC=CC4=CC=C3)NCC2)C=C1O.[H]Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | YS-49 是PI3K/Akt(RhoA 的下游靶标) 的激活剂，可减少 3-甲基胆碱处理的细胞中 RhoA/PTEN 的激活。YS-49 能通过诱导血红素加氧酶 (HO-1) 来抑制血管紧张素 II (Ang II)刺激 VSMC 细胞的增殖。YS-49 是异喹啉化合物生物碱，因能激活心脏β-adrenoceptors而具有强烈的正性肌力作用。 |
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Yun-Choi, H.S., Pyo, M.K., Park, K.M., et al.Antithrombotic effects of YS-49 and YS-51--1-naphthylmethyl analogs of higenamineThromb. Res.104(4),249-255(2001)
Pyo, M.K., Kim, J.M., Jin, J.-L., et al.Effects of higenamine and its 1-naphthyl analogs, YS-49 and YS-51, on platelet TXA2 synthesis and aggregationThromb. Res.120(1),81-86(2007)
Kang, Y.J., Koo, E.B., Lee, Y.S., et al.Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophagesBr. J. Pharmacol.128(2),357-364(1999)
