Dobutamine hydrochloride
Cat. No.：YN321028
| 产品名称: | Dobutamine hydrochloride |
| CAS No.: | 49745-95-1 |
| Chemical Name: | 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-1,2-benzenediol, monohydrochloride |
| Synonyms: | 盐酸多巴酚丁胺 |
| 分子量: | 337.84 |
| 分子式: | C₁₈H₂₄ClNO₃ |
| SMILES: | OC1=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dobutamine hydrochloride 是合成的儿茶酚胺，作用于肾上腺素能受体α1-AR,β1-AR和β2-AR。Dobutamine hydrochloride 是一种选择性的 β1-AR 受体激动剂,对 α1-AR 和 β2-AR 作用相对较弱。Dobutamine hydrochloride 可增加心输出量，矫正低灌注。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Tuttle, R.R., and Mills, J.Dobutamine: Development of a new catecholamine to selectively increase cardiac contractilityCirc. Res.36(1),185-196(1975)
Deighton, N.M., Motomura, A., Bals, S., et al.Characterization of theβadrenoceptor subtype(s) mediating the positive inotropic effects of epinine, dopamine, dobutamine, denopamine and xamoterol in isolated human right atriumJ. Pharmacol. Exp. Ther.262(2),532-538(1992)
Brown, L., Näbauer, M., and Erdmann, E.Dobutamine: Positive inotropy by nonselective adrenoceptor agonism in isolated guinea pig and human myocardiumNaunyn Schmiedebergs Arch. Pharmacol.335(4),385-390(1987)
Innocenti, A., Gülçin, I., Scozzafava, A., et al.Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XVBioorg. Med. Chem. Lett.20(17),5050-5053(2010)
