(S)-Timolol Maleate
Cat. No.：YN321126
| 产品名称: | (S)-Timolol Maleate |
| CAS No.: | 26921-17-5 |
| Chemical Name: | (2S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol, 2Z-butenedioate |
| Synonyms: | (S)-马来酸噻吗洛尔; L-714,465 Maleate; MK 950 |
| 分子量: | 432.49 |
| 分子式: | C₁₇H₂₈N₄O₇S |
| SMILES: | O[C@H](COC1=NSN=C1N2CCOCC2)CNC(C)(C)C.O=C(O)/C=C\C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (S)-Timolol Maleate (L-714,465 Maleate) 是一种非心脏选择性的亲水性 β-肾上腺素受体 (β-adrenoceptor) 阻滞剂。(S)-Timolol Maleate 通过防止房水的产生而被广泛用作眼压（青光眼）的标准药物。(S)-Timolol Maleate 可用于高血压，心绞痛和心肌梗塞的研究。 |
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Baker, J.G.The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptorsBr. J. Pharmacol.144(3),317-322(2005)
Tosi, G., Zironi, F., Caselli, E., et al.Biocatalytic asymmetric synthesis of 9S)- and (R)-timololSynthesis10,1625-1628(2004)
Mehvar, R., and Brocks, D.R.Stereospecific pharmacokinetics and pharmacodynamics of β-adrenergic blockers in humansJ. Pharm. Pharm. Sci.4(2),185-200(2001)
Cheng, J.W., Cheng, S.W., Gao, L.D., et al.Intraocular pressure-lowering effects of commonly used fixed-combination drugs with Timolol: A systematic review and meta-analysisPLoS One7(9),45079(2012)
Li, N., Chen, X.m., Zhou, Y., et al.Travoprost compared with other prostaglandin analogues or timolol in patients with open-angle glaucoma or ocular hypertension: Meta-analysis of randomized controlled trialsClin. Exp. Ophthalmol.34(8),755-764(2006)
