Carvedilol
Cat. No.：YN321368
| 产品名称: | Carvedilol |
| CAS No.: | 72956-09-3 |
| Chemical Name: | 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol |
| Synonyms: | 卡维地洛; BM 14190 |
| 分子量: | 406.47 |
| 分子式: | C₂₄H₂₆N₂O₄ |
| SMILES: | OC(CNCCOC1=CC=CC=C1OC)COC2=CC=CC(N3)=C2C4=C3C=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Carvedilol (BM 14190) 是一种非选择性β/α-1受体阻断剂。Carvedilol 抑制脂质过氧化，IC50为 5 μM。Carvedilol 是一种多用途降压剂，有潜力用于心绞痛和充血性心力衰竭的研究。Carvedilol是一种自噬 (autophagy) 诱导剂，可抑制 NLRP3 炎性体。 |
| IC50和靶点: | |
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Nichols, A.J., Sulpizio, A.C., Ashton, D.J., et al.In vitro pharmacologic profile of the novel beta-adrenoceptor antagonist and vasodilator, carvedilolPharmacology39(5),327-336(1989)
Bristow, M.R., Roden, R.I., Lowes, B.D., et al.The role of third-generation beta-blocking agents in chronic heart failureClin. Cardiol.21(12 Suppl 1),I3-I13(1998)
Myung, S.-W., and Jo, C.-H.Gas chromatograph-mass spectrometric method for the determination of carvedilol and its metabolites in human urineJ. Chromatogr. B Analyt. Technol. Biomed. Life Sci.822(1-2),70-77(2005)
