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Alfuzosin hydrochloride

Cat. No.:YN321414

  • CAS No. :81403-68-1

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    • 产品名称: Alfuzosin hydrochloride
      CAS No.: 81403-68-1
      Chemical Name: N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide, monohydrochloride
      Synonyms:盐酸阿夫唑嗪; SL 77499-10
      分子量:425.91
      分子式:C₁₉H₂₈ClN₅O₄
      SMILES:O=C(C1OCCC1)NCCCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)C.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Alfuzosin盐酸盐是α1肾上腺素受体拮抗剂,可作用于良性前列腺增生(BPH)。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Sinclair, A.J., Davies, I.B., and Warrington, S.J.Alfuzosin and the venous reflex response: Studies in normal subjectsBr. J. Clin. Pharmacol.27,19-22(1989)

      Jardin, A., Bensadoun, H., Delauche-Cavallier, M.C., et al.Alfuzosin for treatment of benign prostatic hypertrophyLancet337,1457-1461(1991)

      Kenny, B.A., Miller, A.M., Williamson, I.J.R., et al.Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: Binding, functional and in vivo studiesBr. J. Pharmacol.118(4),871-878(1996)

      Roehrborn, C.G., and Rosen, R.C.Medical therapy options for aging men with benign prostatic hyperplasia: Focus on alfuzosin 10 mg once dailyClin. Interv. Aging3(3),511-524(2008)

      Nickel, J.C., Sander, S., and Moon, T.D.A meta-analysis of the vascular-related safety profile and efficacy of α-adrenergic blockers for symptoms related to benign prostatic hyperplasiaInt. J. Clin. Pract.62(10),1547-1559(2008)

      Michel, M.C.The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: α-blockers in the treatment of male voiding dysfunction - how do they work and why do they differ in tolerability?J. Pharmacol. Sci.112,151-157(2010)

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