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Prazosin hydrochloride

Cat. No.:YN321416

  • CAS No. :19237-84-4

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    • 产品名称: Prazosin hydrochloride
      CAS No.: 19237-84-4
      Chemical Name: [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanyl-methanone, monohydrochloride
      Synonyms:盐酸哌唑嗪
      分子量:419.86
      分子式:C₁₉H₂₂ClN₅O₄
      SMILES:O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4=CC=CO4.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Prazosin 盐酸盐是 α 肾上腺素阻断剂,可作用于高血压、焦虑和恐慌症等。
      IC50和靶点:
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    • Nagatomo, T., Tsuchihashi, H., Sasaki, S., et al.Displacement by α-adrenergic agonists and antagonists of 3H-prazosin bound to the α-adrenoceptors of the dog aorta and the rat brainJapan J. Pharmacol.37(2),181-187(1985)

      Kristek, F., and Koprdova, R.Long-term effect of prazosin administration on blood pressure, heart and structure of coronary artery of young spontaneously hypertensive ratsJ. Physiol. Pharmacol.62(3),295-301(2011)

      Leiker, A.J., DeGraff, W., Choudhuri, R., et al.Radiation enhancement of head and neck squamous cell carcinoma by the dual PI3K/mTOR inhibitor PF-05212384Clin. Cancer Res.21(12),2792-2801(2015)

      Bylund, D.B., and Ray-Prenger, C.Alpha-2A and alpha-2B adrenergic receptor subtypes: Attenuation of cyclic AMP production in cell lines containing only one receptor subtypeJ. Pharmacol. Exp. Ther.251(2),640-644(1989)

      Paul, P., Lahaye, C., Delagrange, P., et al.Characterization of 2-[125]iodomelatonin binding sites in Syrian hamster peripheral organsJ. Pharmacol. Exp. Ther.290(1),334-340(1999)

      Fernandes, M., Smith, I.S., Weder, A., et al.Prazosin in the treatment of hypertensionClin. Sci. Mol. Med. Suppl.48,181s-184s(1975)

      Verplaetse, T.L., Rasmussen, D.D., Froehlich, J.C., et al.Effects of prazosin, an α1-adrenergic receptor antagonist, on the seeking and intake of alcohol and sucrose in alcohol-preferring (P) ratsAlcohol Clin. Exp. Res.36(5),881-886(2012)

      Skelly, M.J., and Weiner, J.L.Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: Evidence of disrupted noradrenergic signaling in anxiety-related alcohol useBrain Behav.4(4),468-483(2014)

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