Nebivolol hydrochloride
Cat. No.：YN321427
CAS No. ：152520-56-4
| 产品名称: | Nebivolol hydrochloride |
| CAS No.: | 152520-56-4 |
| Chemical Name: | (αR,α'R,2R,2'S)-rel-α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol, monohydrochloride |
| Synonyms: | 盐酸奈必洛尔; R 065824 hydrochloride |
| 分子量: | 441.90 |
| 分子式: | C₂₂H₂₆ClF₂NO₄ |
| SMILES: | FC1=CC=C2C(CC[C@]([C@@H](O)CNC[C@H](O)[C@@]3([H])CCC(C=C(F)C=C4)=C4O3)([H])O2)=C1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nebivolol盐酸盐是β1- 肾上腺素受体选择性抑制剂，IC50为0.8 nM。 |
| IC50和靶点: | |
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Pauwels, P.J., Gommeren, W., Van Lommen, G., et al.The receptor binding profile of the new antihypertensive agent nebivolol and its stereoisomers compared with various β-adrenergic blockersMol. Pharmacol.34(6),843-851(1988)
Georgescu, A., Pluteanu, F., Flonta, M.L., et al.Nebivolol induces a hyperpolarizing effect on smooth muscle cells in the mouse renal artery by activation of beta-2-adrenoceptorsPharmacology81(2),110-117(2008)
Brixius, K., Bundkirchen, A., Bölck, B., et al.Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardiumBr. J. Pharmacol.133(8),1330-1338(2001)
Brehm, B.R., Wolf, S.C., Bertsch, D., et al.Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cellsCardiovasc. Res.49(2),430-439(2001)
Hamed, M.I.A., Darwish, K.M., Soltane, R., et al.β-Blockers bearing hydroxyethylamine and hydroxyethylene as potential SARS-CoV-2 Mpro inhibitors: Rational based design, in silico, in vitro, and SAR studies for lead optimizationRSC Adv.11(56),35536-35558(2021)
