L-(-)-α-Methyldopa
Cat. No.：YN321432
| 产品名称: | L-(-)-α-Methyldopa |
| CAS No.: | 555-30-6 |
| Chemical Name: | 3-hydroxy-α-methyl-L-tyrosine |
| Synonyms: | MK-351; Methyldopa |
| 分子量: | 211.21 |
| 分子式: | C₁₀H₁₃NO₄ |
| SMILES: | OC1=C(O)C=CC(C[C@@](C)(C(O)=O)N)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L-(-)-α-Methyldopa (MK-351) 是一种 α-肾上腺素能激动剂 (对α2- adrenergic receptors有选择性)。L-(-)-α-Methyldopa 是一种前药，在中枢神经系统中被代谢 (alpha-Methylepinephrine)。 |
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Xu, B., Bobek, G., Makris, A., et al.Antihypertensive methyldopa, labetalol, hydralazine, and clonidine reversed tumour necrosis factor-α inhibited endothelial nitric oxide synthase expression in endothelial-trophoblast cellular networksClin. Exp. Pharmacol. Physiol.44(3),421-427(2016)
Onesti, G., Brest, A.N., Novack, P., et al.Pharmacodyamic effects of alpha-methyl dopa in hypertensive subjectsAm. Heart J.67(1),32-38(1964)
LeDoux, J.E., Sakaguchi, A., and Reis, D.J.Alpha-methylDOPA dissociates hypertension, cardiovascular reactivity and emotional behavior in spontaneously hypertensive ratsBrain Res.259(1),69-76(1983)
