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Phentolamine mesylate

Cat. No.:YN321462

  • CAS No. :65-28-1

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    • 产品名称: Phentolamine mesylate
      CAS No.: 65-28-1
      Chemical Name: 3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-phenol, monomethanesulfonate
      Synonyms:甲磺酸酚妥拉明; Phentolamine methanesulfonate
      分子量:377.46
      分子式:C₁₈H₂₃N₃O₄S
      SMILES:CS(O)(=O)=O.CC1=CC=C(N(C2=CC(O)=CC=C2)CC3=NCCN3)C=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Phentolamine mesylate (Phentolamine methanesulfonate) 是一种可逆的,非选择性和具有口服活性的α1和α2肾上腺素能受体阻滞剂,可使血管扩张以减少周围血管阻力。Phentolamine mesylate 可用于研究嗜铬细胞瘤相关的高血压,心力衰竭和勃起功能障碍。
      IC50和靶点:
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    • Lomasney, J.W., Cotecchia, S., Lorenz, W., et al.Molecular cloning and expression of the cDNA for the α1A-adrenergic receptor. The gene for which is located on human chromosome 5J. Biol. Chem.266(10),6365-6369(1991)

      Millan, M.J., Newman-Tancredi, A., Audinot, V., et al.Agonist and antagonist actions of yohimbine as compared to fluparoxan at α2-adrenergic receptors (AR)s, serotonin (5-HT)1A, 5-HT1B, 5-HT1D and dopamine D2 and D3 receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive statesSynapse35(2),79-95(2000)

      O'Rourke, M.F., Iversen, L.J., Lomasney, J.W., et al.Species orthologs of the Alpha-2A adrenergic receptor: The pharmacological properties of the bovine and rat receptors differ from the human and porcine receptorsJ. Pharmacol. Exp. Ther.271(2),735-740(1994)

      Richelson, E., and Nelson, A.Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitroJ. Pharmacol. Exp. Ther.230(1),94-102(1984)

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