Naftopidil hydrochloride
Cat. No.：YN321481
| 产品名称: | Naftopidil hydrochloride |
| CAS No.: | 1164469-60-6 |
| Chemical Name: | 4-(2-methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol, monohydrochloride |
| Synonyms: | KT-611 hydrochloride; BM-15275 hydrochloride |
| 分子量: | 428.95 |
| 分子式: | C₂₄H₂₉ClN₂O₃ |
| SMILES: | [H]Cl.OC(CN1CCN(C(C=CC=C2)=C2OC)CC1)COC3=CC=CC4=CC=CC=C34 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Naftopidil hydrochloride (KT-611 hydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，具有抗增殖作用。Naftopidil dihydrochloride 可用于前列腺增生的研究。 |
| IC50和靶点: | [{name:"Alpha-1A adrenergic receptor:3.7 nM (Ki)"},{name: "Alpha-1B adrenergic receptor:20 nM (Ki)"},{name: "Alpha-1D adrenergic receptor:1.2 nM (Ki)"}] |
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Muramatsu, I., Yamanaka, K., and Kigoshi, S.Pharmacological profile of the novel α-adrenoceptor antagonist KT-611 (naftopidil)Jpn. J. Pharmacol.55(3),391-398(1991)
Masumori, N.Naftopidil for the treatment of urinary symptoms in patients with benign prostatic hyperplasiaTher. Clin. Risk Manag.7,227-238(2011)
Kanda, H., Ishii, K., Ogura, Y., et al.Naftopidil, a selective α-1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrestInt. J. Cancer122(2),444-451(2008)
