Phenoxybenzamine hydrochloride
Cat. No.：YN321496
| 产品名称: | Phenoxybenzamine hydrochloride |
| CAS No.: | 63-92-3 |
| Chemical Name: | N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine, monohydrochloride |
| Synonyms: | 盐酸酚苄明 |
| 分子量: | 340.29 |
| 分子式: | C₁₈H₂₃Cl₂NO |
| SMILES: | CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Phenoxybenzamine hydrochloride 是具有选择行的α-adrenoceptor和calmodulin的抑制剂，是一种常用的抗高血压药。 |
| IC50和靶点: | |
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Frang, H., Cockcroft, V., Karskela, T., et al.Phenoxybenzamine binding reveals the helical orientation of the third transmembrane domain of adrenergic receptorsJ. Biol. Chem.276(33),31279-31284(2001)
McPherson, G.A., Krstew, E., and Malta, E.Effects of phenoxybenzamine on responses to some receptor agonists and calcium in vitroClin. Exp. Pharmacol. Physiol.12(5),455-464(1985)
Inchiosa, M.A., Jr.Anti-tumor activity of phenoxybenzamine and its inhibition of histone deacetylasesPLoS One13(6):e0198514,(2018)
Timmermans, P.B., Thoolen, M.J., Mathy, M.J., et al.Effects of the irreversible α-adrenoceptor antagonists phenoxybenzamine and benextramine on the effectiveness of nifedipine in inhibiting α1- and α2-adrenoceptor mediated vasoconstriction in pithed ratsNaunyn Schmiedebergs Arch. Pharmacol.329(4),404-413(1985)
Rau, T.F., Kothiwal, A., Rova, A., et al.Phenoxybenzamine is neuroprotective in a rat model of severe traumatic brain injuryInt. J. Mol. Sci.15(1),1402-1417(2014)
