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Sotalol D6 hydrochloride

Cat. No.:YN321499

  • CAS No. :1246820-85-8

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    • 参考文献
    • 产品名称: Sotalol D6 hydrochloride
      CAS No.: 1246820-85-8
      Chemical Name: N-(4-(1-hydroxy-2-((propan-2-yl-1,1,1,3,3,3-d6)amino)ethyl)phenyl)methanesulfonamide, monohydrochloride
      Synonyms:Sotalol D6 hydrochloride
      分子量:314.86
      分子式:C₁₂H₁₅D₆ClN₂O₃S
      SMILES:OC(C1=CC=C(NS(C)(=O)=O)C=C1)CNC(C([2H])([2H])[2H])C([2H])([2H])[2H].[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Sotalol D6 hydrochloride 是 Sotalol hydrochloride 的氘代物。Sotalol hydrochloride 是一种非选择性竞争性 β-肾上腺素能受体拮抗剂,它还通过抑制钾通道而表现出 III 类抗心律不齐的特性。
      IC50和靶点:
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    • Lis, R., Morgan, T.K., Jr., Marisca, A.J., et al.Synthesis of novel (aryloxy) propanolamines and related compounds possessing both class II and class III antiarrhythmic activityJ. Med. Chem33(10),2883-2891(1990)

      Antonaccio, M.J., and Gomoll, A.Pharmacology, pharmacodynamics and pharmacokinetics of sotalolAm. J. Cardiol.65(2),12A-21A(1990)

      Komeichi, K., Tohse, N., Nakaya, H., et al.Effects of N-acetylprocainamide and sotalol on ion currents in isolated guinea-pig ventricular myocytesEur. J. Pharm.187(3),313-322(1990)

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